Geminin Rabbit Polyclonal Antibody (R1204-2)

UNIPROT #

O75496

PROTEIN NAME

Geminin

SYNONYMS

DNA replication inhibitor antibody;Gem antibody;GEMI_HUMAN antibody;Geminin antibody;Geminin DNA replication inhibitor antibody;GMNN antibody;OTTHUMP00000039393 antibody;RP3 369A17.3 antibody

SEQUENCE SIMILARITIES

Belongs to the geminin family.

DEVELOPMENTAL STAGE

Absent during G1 phase, accumulates during S, G2, and M phases, and disappears at the time of the metaphase-anaphase transition.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated during mitosis. Phosphorylation at Ser-184 by CK2 results in enhanced binding to Hox proteins and more potent inhibitory effect on Hox transcriptional activity.

SUBCELLULAR LOCATION

Nucleus, cytoplasm

FUNCTION

Geminin is a nuclear protein that is present in most eukaryotics and highly conserved across species. Numerous functions have been elucidated for Geminin including roles in metazoan cell cycle, cellular proliferation, cell lineage commitment, and neural differentiation. During S phase, geminin is a negative regulator of DNA replication. In many cancer cell lines, inhibition of geminin by RNAi results in re-replication of portions of the genome, which leads to aneuploidy.