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GFAP Recombinant Rabbit Monoclonal Antibody [SA03-04] (ET1601-23)

Price: Regular price $385.00

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Catalog# ET1601-23

Rabbit Monoclonal to GFAP

Tested for

  • WB

  • IHC-P

  • IF-Tissue

  • IHC-Fr

  • mIHC

  • IP

Reacts with

  • Human

  • Mouse

  • Rat

  • Cynomolgus monkey

  • Pig

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

GFAP Recombinant Rabbit Monoclonal Antibody [SA03-04] (ET1601-23)

Immunogen

Synthetic peptide within human gfap aa 1-50 / 432.

Host

Rabbit

Positive Control

Human brain tissue lysate, rat brain tissue lysate, human cerebellum tissue lysate, mouse brain tissue, rat brain tissue, human brain tissue, human glioblastoma tissue, mouse spinal cord tissue, rat spinal cord tissue, mouse cerebral cortex tissue, rat cerebral cortex tissue, mouse cerebellum tissue, rat cerebellum tissue, mouse hippocampus tissue, rat hippocampus tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SA03-04

RRID

AB_3069606

APPLICATION DILUTION

  • WB

  • 1:5,000

  • IHC-P

  • 1:500-1:1,000

  • IF-Tissue

  • 1:200-1:500

  • IHC-Fr

  • 1:200-1:500

  • mIHC

  • 1:1,000-1:10,000

  • IP

  • Use at an assay dependent concentration.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 50 kDa

Isotype

IgG

TARGET

UNIPROT #

P14136

PROTEIN NAME

GFAP

SYNONYMS

wu:fb34h11 antibody;ALXDRD antibody;cb345 antibody;etID36982.3 antibody;FLJ42474 antibody;FLJ45472 antibody;GFAP antibody;GFAP_HUMAN antibody;gfapl antibody;Glial fibrillary acidic protein antibody;Intermediate filament protein antibody;wu:fk42c12 antibody;xx:af506734 antibody;zgc:110485 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Expressed in cells lacking fibronectin.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by PKN1.

SUBCELLULAR LOCATION

Cytoplasm

FUNCTION

Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans. It is a type III intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS), including astrocytes and ependymal cells during development. GFAP has also been found to be expressed in glomeruli and peritubular fibroblasts taken from rat kidneys, Leydig cells of the testis in both hamsters and humans, human keratinocytes, human osteocytes and chondrocytes and stellate cells of the pancreas and liver in rats. GFAP is closely related to the other three non-epithelial type III IF family members, vimentin, desmin and peripherin, which are all involved in the structure and function of the cell’s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength as well as the shape of cells, but its exact function remains poorly understood, despite the number of studies using it as a cell marker.

CITATIONS

  • Du Junbao,et al

    Nitric oxide donor S‐Nitroso‐N‐acetyl penicillamine for hepatic stellate cells to restore quiescence

  • Hu Qidi,et al

    Adenosine A2A receptor antagonist KW6002 protects against A53T mutant alpha-synuclein-induced brain damage and neuronal apoptosis in Parkinson's disease mice by restoring autophagic flux

  • Multimodal investigation reveals the neuroprotective mechanism of Angong Niuhuang pill for intracerebral hemorrhage: Converging bioinformatics, network pharmacology,and experimental validation

  • Liu Lin,et al

    NKG2D knockdown improves hypoxic-ischemic brain damage by inhibiting neuroinflammation in neonatal mice

  • Wang Xiaohong,et al

    Deciphering the Therapeutic Potential of SheXiangXinTongNing: Interplay between Gut Microbiota and Brain Metabolomics in a CUMS Mice Model, with a Focus on Tryptophan Metabolism

  • Qiangping Wang,et al

    RNF13 protects neurons against ischemia-reperfusion injury via stabilizing p62-mediated Nrf2/HO-1 signaling pathway

  • Modulation of microglial polarization by sequential targeting surface-engineered exosomes improves therapy for ischemic stroke

  • Neuroprotective effects of saffron on the late cerebral ischemia injury through inhibiting astrogliosis and glial scar formation in rats

  • Lingman Wang,et al

    Identification and verification of key molecules in the epileptogenic process of focal cortical dysplasia

  • Catalpol rescues cognitive deficits by attenuating amyloid β plaques and neuroinflammation.

  • Shao, R., Wang, X., Xu, T., Xia, Y., & Cui, D.

    The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest

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