Giantin Recombinant Rabbit Monoclonal Antibody [PSH03-86] (HA722052)

UNIPROT #

Q14789

PROTEIN NAME

Giantin

SYNONYMS

372 kDa Golgi complex associated protein antibody;372 kDa Golgi complex-associated protein antibody;GCP antibody;GCP372 antibody;Giantin antibody;GOGB1_HUMAN antibody;GOLGB1 antibody;Golgi autoantigen golgin subfamily a member 1 antibody;Golgi autoantigen golgin subfamily b macrogolgin (with transmembrane signal) 1 antibody;Golgi autoantigen, golgin subfamily b, macrogolgin 1 antibody;Golgi complex associated protein 372kDa antibody;Golgi complex-associated protein 372kDa antibody;Golgin B1 antibody;Golgin B1, golgi integral membrane protein antibody;Golgin subfamily B member 1 antibody;GOLIM1 antibody;Macrogolgin antibody;MGC33154 antibody

SUBCELLULAR LOCATION

Golgi apparatus membrane.

FUNCTION

Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene. Giantin is located at the cis-medial rims of the Golgi apparatus and is part of the Golgi matrix that is responsible for membrane trafficking in secretory pathway of proteins. This function is key for proper localisation of proteins at the plasma membrane and outside the cell (extracellular region) which is important for cell function that is dependent on for example receptors and the extracellular matrix function. Recent animal model knockout studies of GOLGB1 in mice, rat, and zebrafish have shown that phenotypes are different between species ranging from mild to severe craniofacial defects in the rodent models to just minor size defects in zebrafish. However, in adult zebrafish a tumoral calcinosis-like phenotype was observed, and in humans such phenotype has been linked to defective glycosyltransferase function (e.g. GALNT3 protein).