Glucosidase 2 subunit beta Rabbit Polyclonal Antibody (HA500152)

UNIPROT #

P14314

PROTEIN NAME

Glucosidase 2 subunit beta

SYNONYMS

80K-H protein antibody;AGE-binding receptor 2 antibody;AGE-R2 antibody;G19P1 antibody;GLU2B_HUMAN antibody;Glucosidase 2 subunit beta antibody;Glucosidase II beta subunit antibody;Glucosidase II subunit beta antibody;Hepatocystin antibody;PCLD antibody;PKCSH antibody;PLD1 antibody;PRKCSH antibody;Protein kinase C substrate 60.1 kDa protein heavy chain antibody;Protein kinase C substrate 80 Kda protein antibody;Protein kinase C substrate 80K-H antibody;Protein kinase C substrate, 80 Kda protein antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum.

FUNCTION

This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).