GOT1 Rabbit Polyclonal Antibody (ER1802-48)

UNIPROT #

P17174

PROTEIN NAME

GOT1

SYNONYMS

CGI-141 antibody;GCT2 antibody;Germ cell tumor 2 antibody;Golgi transport 1 homolog B antibody;Golgi transport 1B antibody;GOLT1B antibody;GOT1 antibody;GOT1B_HUMAN antibody;hGOT1a antibody;Putative NF-kappa-B-activating protein 470 antibody;Vesicle transport protein GOT1B antibody;YMR292W antibody

SEQUENCE SIMILARITIES

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H2S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.