GPA33 Recombinant Rabbit Monoclonal Antibody [JE49-54] (ET7109-93)

UNIPROT #

Q99795

PROTEIN NAME

GPA33

SYNONYMS

A33 antibody;Cell surface A33 antigen antibody;Cell surface A33 antigen precursor antibody;Glycoprotein A33 (transmembrane) antibody;Glycoprotein A33 antibody;Gpa33 antibody;GPA33_HUMAN antibody;MGC129986 antibody;MGC129987 antibody;OTTHUMP00000032346 antibody;Transmembrane glycoprotein A33 antibody

TISSUE SPECIFICITY

Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated, contains approximately 8 kDa of N-linked carbohydrate.; Palmitoylated.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. These results suggest that GPA33 might be a candidate marker for the diagnosis and therapy of colorectal cancer. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.