GPCR RDC1/CXCR-7 Rabbit Polyclonal Antibody (R1512-3)

UNIPROT #

P25106

PROTEIN NAME

GPCR RDC1/CXCR-7

SYNONYMS

ACKR3 antibody;atypical chemokine receptor 3 antibody;C X C chemokine receptor type 7 antibody;C-X-C chemokine receptor type 7 antibody;Chemokine (C-X-C motif) receptor 7 antibody;Chemokine C X C motif receptor 7 antibody;Chemokine orphan receptor 1 antibody;CMKOR1 antibody;CXC R7 antibody;CXC-R7 antibody;CXCR 7 antibody;CXCR-7 antibody;CXCR7 antibody;CXCR7_HUMAN antibody;G protein coupled receptor 159 antibody;G protein coupled receptor antibody;G protein coupled receptor RDC1 homolog antibody;G-protein coupled receptor 159 antibody;G-protein coupled receptor RDC1 homolog antibody;GPCR RDC1 antibody;GPR159 antibody;GPRN1 antibody;RDC 1 antibody;RDC-1 antibody;RDC1 antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Endosome, Membrane

FUNCTION

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.