GRB2 Recombinant Rabbit Monoclonal Antibody [JE49-73] (HA721923)

UNIPROT #

P62993

PROTEIN NAME

GRB2

SYNONYMS

Abundant SRC homology antibody;Adapter protein GRB2 antibody;ASH antibody;Ash protein antibody;EGFRBP GRB2 antibody;Epidermal growth factor receptor binding protein antibody;Epidermal growth factor receptor binding protein GRB2 antibody;GRB 2 antibody;GRB2 adapter protein antibody;Grb2 antibody;GRB2_HUMAN antibody;Grb3 3 antibody;Growth factor receptor bound protein 2 antibody;Growth factor receptor bound protein 3 antibody;Growth factor receptor-bound protein 2 antibody;HT027 antibody;MST084 antibody;MSTP084 antibody;NCKAP2 antibody;OTTHUMP00000166096 antibody;OTTHUMP00000166097 antibody;OTTHUMP00000166098 antibody;Protein ash antibody;SEM5 antibody;SH2/SH3 adapter GRB2 antibody

SUBCELLULAR LOCATION

Cytoplasm. Endosome. Golgi apparatus. Nucleus.

FUNCTION

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.