GRB2 Rabbit Polyclonal Antibody (ER31203)

UNIPROT #

P62993

PROTEIN NAME

GRB2

SYNONYMS

Abundant SRC homology antibody;Adapter protein GRB2 antibody;ASH antibody;Ash protein antibody;EGFRBP GRB2 antibody;Epidermal growth factor receptor binding protein antibody;Epidermal growth factor receptor binding protein GRB2 antibody;GRB 2 antibody;GRB2 adapter protein antibody;Grb2 antibody;GRB2_HUMAN antibody;Grb3 3 antibody;Growth factor receptor bound protein 2 antibody;Growth factor receptor bound protein 3 antibody;Growth factor receptor-bound protein 2 antibody;HT027 antibody;MST084 antibody;MSTP084 antibody;NCKAP2 antibody;OTTHUMP00000166096 antibody;OTTHUMP00000166097 antibody;OTTHUMP00000166098 antibody;Protein ash antibody;SEM5 antibody;SH2/SH3 adapter GRB2 antibody

SEQUENCE SIMILARITIES

Belongs to the GRB2/sem-5/DRK family.

SUBCELLULAR LOCATION

Cytoplasm, nucleus.

FUNCTION

Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene. The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the sem-5 gene of Caenorhabditis elegans, which is involved in the signal transduction pathway. Grb2 is widely expressed and is essential for multiple cellular functions. Inhibition of Grb2 function impairs developmental processes in various organisms and blocks transformation and proliferation of various cell types. It is thus not surprising that targeted gene disruption of Grb2 in mice is lethal at an early embryonic stage. Grb2 is best known for its ability to link the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases, ERK1,2. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain. Grb2 has two closely related proteins with similar domain organizations, Gads and Grap. Gads and Grap are expressed specifically in hematopoietic cells and function in the coordination of tyrosine kinase mediated signal transduction.