GSDMA Rabbit Polyclonal Antibody (HA500498)
Catalog# HA500498
Rabbit Polyclonal to GSDMA
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WB
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Human
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Rat
Positive control:
Lane 1: Human skin tissue lysate
Lane 2: Rat skin tissue lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
GSDMA Rabbit Polyclonal Antibody (HA500498)
Immunogen
Recombinant protein within human gsdma aa 1-200.
Host
Rabbit
Positive Control
Human skin tissue lysate, rat skin tissue lysate.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:1,000-1:2,000
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 49 kDa.
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
GSDMA
SYNONYMS
FKSG9 antibody;Gasdermin 1 antibody;Gasdermin A antibody;Gasdermin-1 antibody;Gasdermin-A antibody;GSDM antibody;GSDM1 antibody;GSDMA antibody;GSDMA_HUMAN antibody
SUBCELLULAR LOCATION
Cytosol, perinuclear region; Cell membrane.
FUNCTION
May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)- bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity. The physiological relevance of these observations is unknown (Probable).
CITATIONS
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Jiang Xueqin,et al
NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation
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WB
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Mouse
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Citation
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