GSDMD Mouse Monoclonal Antibody [A8D8] (HA601047)

UNIPROT #

P57764

PROTEIN NAME

GSDMD

SYNONYMS

1810036L03Rik antibody;DF 5L antibody;DF5L antibody;DFNA 5L antibody;DFNA5L antibody;FKSG 10 antibody;FKSG10 antibody;FLJ12150 antibody;Gasdermin antibody;Gasdermin D antibody;Gasdermin domain containing 1 antibody;Gasdermin domain containing protein 1 antibody;Gasdermin domain-containing protein 1 antibody;Gasdermin-D antibody;GasderminD antibody;GSDMD antibody;GSDMD_HUMAN antibody;GSDMDC 1 antibody;GSDMDC1 antibody

SUBCELLULAR LOCATION

Cytosol, Inflammasome; Secreted, Cell membrane.

FUNCTION

Gasdermin D (GSDMD) is a protein that in humans is encoded by the GSDMD gene on chromosome 8. It belongs to the gasdermin family which is conserved among vertebrates and comprises six members in humans, GSDMA, GSDMB, GSDMC, GSDMD, GSDME (DFNA5) and DFNB59 (Pejvakin). Members of the gasdermin family are expressed in a variety of cell types including epithelial cells and immune cells. GSDMA, GSDMB, GSDMC, GSDMD and GSDME have been suggested to act as tumour suppressors. Several current studies have revealed that GSDMD serves as a specific substrate of inflammatory caspases (caspase-1, -4, -5 and -11) and as an effector molecule for the lytic and highly inflammatory form of programmed cell death known as pyroptosis. Hence, GSDMD is an essential mediator of host defence against microbial infection and danger signals. The pore-forming activity of the N-terminal cleavage product causes cell swelling and lysis to prevent intracellular pathogens from replicating, and is required for the release of cytoplasmic content such as the inflammatory cytokine interleukin-1β (IL-1β) into the extracellular space to recruit and activate immune cells to the site of infection. GSDMD has an additional potential role as an antimicrobial by binding to cardiolipin (CL) and form pores on bacterial membranes. Mutation of GSDMD is associated with various genetic diseases and human cancers, including brain, breast, lung, urinary bladder, cervical, skin, oral cavity, pharynx, colon, liver, cecum, stomach, pancreatic, prostate, oesophageal, head and neck, hematologic, thyroid and uterine cancers.