GSTA4 Recombinant Rabbit Monoclonal Antibody [JE61-65] (HA721825)

UNIPROT #

O15217

PROTEIN NAME

GSTA4

SYNONYMS

DKFZp686D21185 antibody;Glutathione S alkyltransferase A4 antibody;Glutathione S aralkyltransferase A4 antibody;Glutathione S aryltransferase A4 antibody;Glutathione S transferase A4 4 antibody;Glutathione S transferase A4 antibody;Glutathione S transferase alpha 4 antibody;Glutathione S-transferase A4 antibody;Glutathione S-transferase A4-4 antibody;Glutathione transferase A4 4 antibody;GST class alpha member 4 antibody;GST class-alpha member 4 antibody;GSTA4 4 antibody;GSTA4 antibody;GSTA4_HUMAN antibody;GTA4 antibody;OTTHUMP00000016624 antibody;OTTHUMP00000016625 antibody;S (hydroxyalkyl)glutathione lyase A4 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis.