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HDAC6 Recombinant Rabbit Monoclonal Antibody [JJ09-09] (ET1701-66)

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Catalog# ET1701-66

Rabbit Monoclonal to HDAC6

Tested for

  • WB

  • IF-Tissue

  • IHC-P

  • IP

Reacts with

  • Human

  • Monkey

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

HDAC6 Recombinant Rabbit Monoclonal Antibody [JJ09-09] (ET1701-66)

Immunogen

Synthetic peptide within human hdac6 aa 1-50 / 1,215.

Host

Rabbit

Positive Control

HeLa cell lysate, K-562 cell lysate, Jurkat cell lysate, COS-1 cell lysate, HCT 116 cell lysate, human kidney tissue, human breast tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JJ09-09

RRID

AB_3070230

APPLICATION DILUTION

  • WB

  • 1:1,000-1:5,000

  • IF-Tissue

  • 1:50-1:200

  • IHC-P

  • 1:50-1:400

  • IP

  • Use at an assay dependent concentration.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 131 kDa

Isotype

IgG

TARGET

UNIPROT #

Q9UBN7

PROTEIN NAME

HDAC6

SYNONYMS

CPBHM antibody;FLJ16239 antibody;HD 6 antibody;HD6 antibody;HDAC 6 antibody;HDAC6 antibody;HDAC6_HUMAN antibody;Histone deacetylase 6 (HD6) antibody;Histone deacetylase 6 antibody;JM 21 antibody;JM21 antibody;KIAA0901 antibody;OTTHUMP00000032398 antibody;OTTHUMP00000197663 antibody;PPP1R90 antibody;Protein phosphatase 1 regulatory subunit 90 antibody

SEQUENCE SIMILARITIES

Belongs to the histone deacetylase family. HD type 2 subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by AURKA.; Ubiquitinated. Its polyubiquitination however does not lead to its degradation.; Sumoylated in vitro.

SUBCELLULAR LOCATION

Cell projection, Cytoplasm, Cytoskeleton, Nucleus.

FUNCTION

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBPassociated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6, have been identified as histone deacetylases.

CITATIONS

  • HDAC6 Degrades nsp8 of Porcine Deltacoronavirus through Deacetylation and Ubiquitination to Inhibit Viral Replication

  • Dietary glucose increases glucose absorption and lipid deposition via SGLT1/2 signaling and acetylated ChREBP in the intestine and isolated intestinal epithelial cells of yellow catfish

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