HDAC9 Recombinant Rabbit Monoclonal Antibody [JU30-44] (ET1706-36)

UNIPROT #

Q9UKV0

PROTEIN NAME

HDAC9

SYNONYMS

HD 7 antibody;HD 7B antibody;HD 9 antibody;HD7 antibody;HD7B antibody;HD9 antibody;HDAC 7 antibody;HDAC 7B antibody;HDAC 9 antibody;HDAC 9B antibody;HDAC 9FL antibody;HDAC antibody;HDAC7 antibody;HDAC7B antibody;HDAC9 antibody;HDAC9_HUMAN antibody;HDAC9B antibody;HDAC9FL antibody;HDRP antibody;Histone deacetylase 4/5 related protein antibody;Histone deacetylase 7 antibody;Histone deacetylase 7B antibody;Histone deacetylase 9 antibody;Histone deacetylase 9A antibody;Histone deacetylase related protein antibody;Histone deacetylase-related protein antibody;KIAA0744 antibody;MEF2 interacting transcription repressor MITR antibody;MEF2 interacting transcription repressor protein antibody;MEF2-interacting transcription repressor MITR antibody;MITR antibody

SEQUENCE SIMILARITIES

Belongs to the histone deacetylase family. HD type 2 subfamily.

TISSUE SPECIFICITY

Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on Ser-220 and Ser-450; which promotes 14-3-3-binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240; which impairs nuclear accumulation (By similarity). Isoform 7 is phosphorylated on Tyr-1010. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import.; Sumoylated.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is a critical component of transcriptional regulation and the acetylation of nucleosomal histones is a major source of this remodeling. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1-9. HDAC9 and HDAC9a are two alternatively spliced isoforms of HDAC9. HDAC9a is 132 amino acids shorter than HDAC9, but both isoforms contain the HDAC catalytic domain, remain capable of deacetylase activity and repress myoctye enhancer-binding factor 2-mediated transcription.