HE4 Recombinant Rabbit Monoclonal Antibody [JF62-09] (ET1702-61)

UNIPROT #

Q14508

PROTEIN NAME

HE4

SYNONYMS

dJ461P17.6 antibody;EDDM4 antibody;epididymal protein 4 antibody;Epididymal secretory protein E4 antibody;Epididymis specific whey acidic protein type four disulfide core antibody;HE 4 antibody;Major epididymis specific protein E4 antibody;Major epididymis-specific protein E4 antibody;MGC57529 antibody;Putative protease inhibitor WAP5 antibody;WAP 5 antibody;WAP domain containing protein HE4 antibody;WAP domain containing protein HE4 V4 antibody;WAP four disulfide core domain 2 antibody;WAP four disulfide core domain protein 2 antibody;WAP four-disulfide core domain protein 2 antibody;WAP5 antibody;WFDC 2 antibody;WFDC2 antibody;WFDC2_HUMAN antibody

TISSUE SPECIFICITY

Expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines. Initially described as being exclusively transcribed in the epididymis.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

HE4 (whey acidic protein (WAP)-type four-disulfide core-2, WFDC2) is a small secretory protein that may influence sperm maturation. HE4 gene expression is high in pulmonary epithelial cells and in some ovarian cancers. HE4 protein has a WAP motif that contains eight cysteines forming four disulfide bonds at the core of the protein. The WAP motif functions as a protease inhibitor in many of the family members that contain them.