HIF-1 beta Recombinant Rabbit Monoclonal Antibody [ST05-25] (ET1609-67)

UNIPROT #

P27540

PROTEIN NAME

HIF-1 beta

SYNONYMS

arnT antibody;ARNT protein antibody;ARNT_HUMAN antibody;Aryl hydrocarbon receptor nuclear translocator antibody;bHLHe2 antibody;Class E basic helix-loop-helix protein 2 antibody;Dioxin receptor antibody;Dioxin receptor nuclear translocator antibody;Drnt antibody;HIF 1 beta antibody;HIF 1beta antibody;HIF-1-beta antibody;HIF1-beta antibody;HIF1B antibody;HIF1beta antibody;Hypoxia Inducible Factor 1 antibody;Hypoxia inducible factor 1 beta antibody;Hypoxia-inducible factor 1-beta antibody;nuclear translocator antibody;Tango antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

AhR, Arnt 1, Arnt 2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common “PAS” motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. Arnt 2 (aryl hydrocarbon receptor nuclear translocator 2), also known as Hif-2b or bHLHe1, is a 712 amino acid nuclear protein that is exclusively expressed in adult brain and kidney. Containing a basic helix-loop-helix (bHLH) domain, a PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains, Arnt 2 specifically recognizes the xenobiotic response element (XRE).