HLA-DR Mouse Monoclonal Antibody [10-D8] (M1701-5)

UNIPROT #

P01903

PROTEIN NAME

HLA-DR

SYNONYMS

DR alpha chain antibody;DR alpha chain precursor antibody;DRA_HUMAN antibody;DRB1 antibody;DRB4 antibody;Histocompatibility antigen HLA DR alpha antibody;HLA class II histocompatibility antigen antibody;HLA class II histocompatibility antigen DR alpha chain antibody;HLA DR1B antibody;HLA DR3B antibody;HLA DRA antibody;HLA DRA1 antibody;HLA DRB1 antibody;HLA DRB3 antibody;HLA DRB4 antibody;HLA DRB5 antibody;HLA-DRA antibody;HLADR4B antibody;HLADRA1 antibody;HLADRB antibody;Major histocompatibility complex class II DR alpha antibody;Major histocompatibility complex class II DR beta 1 antibody;Major histocompatibility complex class II DR beta 3 antibody;Major histocompatibility complex class II DR beta 4 antibody;Major histocompatibility complex class II DR beta 5 antibody;MGC117330 antibody;MHC cell surface glycoprotein antibody;MHC class II antigen DRA antibody;MHC II antibody;MLRW antibody

SEQUENCE SIMILARITIES

Belongs to the MHC class II family.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by MARCH1 or MARCH8 at Lys-244 leading to down-regulation of MHC class II. When associated with ubiquitination of the beta subunit of HLA-DR: HLA-DRB4 'Lys-254', the down-regulation of MHC class II may be highly effective.

SUBCELLULAR LOCATION

Cell membrane. Endoplasmic reticulum membrane.

FUNCTION

Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (β-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.