HLA E Rabbit Polyclonal Antibody (HA500299)

UNIPROT #

P13747

PROTEIN NAME

HLA E

SYNONYMS

HLA class I histocompatibility antigen E alpha chain antibody;EA1.2 antibody;EA2.1 antibody;HLA 6.2 antibody;HLA class I histocompatibility antigen alpha chain E antibody;HLA class I histocompatibility antigen E alpha chain precursor antibody;HLA class I histocompatibility antigen E alpha chain precursor antibody;HLA6.2 antibody;HLAE antibody;Lymphocyte antigen antibody;Major histocompatibility complex class I E antibody;MHC antibody;MHC class I antigen E antibody;MHC HLA E alpha 1 antibody;MHC HLA E alpha 2.1 antibody;QA1 antibody

SUBCELLULAR LOCATION

Golgi apparatus membrane, Cell membrane, Secreted.

FUNCTION

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.