HNF1 alpha Rabbit Polyclonal Antibody (HA500285)

UNIPROT #

P20823

PROTEIN NAME

HNF1 alpha

SYNONYMS

Albumin proximal factor antibody;Hepatic nuclear factor 1 alpha antibody;Hepatic nuclear factor 1 antibody;Hepatic transcription factor 1 alpha antibody;Hepatic transcription factor 1 antibody;Hepatocyte nuclear factor 1-alpha antibody;HNF 1 antibody;HNF 1A antibody;HNF-1-alpha antibody;HNF-1A antibody;hnf1a antibody;HNF1A_HUMAN antibody;Interferon production regulator factor antibody;LF B1 antibody;LF B1 hepatic nuclear factor antibody;LFB 1 antibody;LFB1 antibody;LFB1 hepatic nuclear factor antibody;Liver specific transcription factor LF B1 antibody;Liver specific transcription factor LFB1 antibody;Liver-specific transcription factor LF-B1 antibody;Maturity onset diabetes of the young 3 antibody;MODY 3 antibody;MODY3 antibody;TCF 1 antibody;TCF-1 antibody;TCF1 antibody;Transcription factor 1 antibody;Transcription factor 1 hepatic antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms.