HRP Conjugated CCR7 Recombinant Rabbit Monoclonal Antibody [SR36-04] (HA721185)

UNIPROT #

P32248

PROTEIN NAME

CCR7

SYNONYMS

BLR 2 antibody;BLR2 antibody;C C chemokine receptor type 7 antibody;C C CKR 7 antibody;C-C chemokine receptor type 7 antibody;C-C CKR-7 antibody;CC chemokine receptor 7 antibody;CC chemokine receptor type 7 antibody;CC CKR 7 antibody;CC-CKR-7 antibody;CCCKR7 antibody;CCR 7 antibody;CCR-7 antibody;Ccr7 antibody;CCR7_HUMAN antibody;CD 197 antibody;CD197 antibody;CD197 antigen antibody;CDw197 antibody;Chemokine (C C motif) receptor 7 antibody;Chemokine (C C) receptor 7 antibody;Chemokine C C motif receptor 7 antibody;Chemokine C C receptor 7 antibody;Chemokine receptor 7 antibody;Chemokine receptor 7-like protein antibody;CMKBR7 antibody;EBI 1 antibody;EBI1 antibody;Ebi1h antibody;EBV Induced G Protein Coupled Receptor 1 antibody;EBV-induced G-protein coupled receptor 1 antibody;Epstein Barr virus induced G protein coupled receptor antibody;Epstein Barr virus induced gene 1 antibody;Epstein-Barr virus-induced G-protein coupled receptor 1 antibody;EVI 1 antibody;EVI1 antibody;Lymphocyte Specific G Protein Coupled Peptide Receptor antibody;MGC108519 antibody;MIP 3 beta receptor antibody;MIP-3 beta receptor antibody;MIP3 Beta Receptor antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family.

TISSUE SPECIFICITY

Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene. Two ligands have been identified for this receptor: the chemokines (C-C motif) ligand 19 (CCL19/ELC) and (C-C motif) ligand 21 (CCL21). CCR7 has also recently been designated CD197 (cluster of differentiation 197). The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. CCR7 has been shown to stimulate dendritic cell maturation. CCR7 is also involved in homing of T cells to various secondary lymphoid organs such as lymph nodes and the spleen as well as trafficking of T cells within the spleen. Activation of Dendritic cells in peripheral tissues induces CCR7 expression on the cell's surface, which recognize CCL19 and CCL21 produced in the Lymph node and increases dendritic cell expression of co-stimulation molecules (B7), and MHC class I or MHC class II.