HSD11B1 Recombinant Rabbit Monoclonal Antibody [JU18-39] (ET1706-27)

UNIPROT #

P28845

PROTEIN NAME

HSD11B1

SYNONYMS

11 beta HSD 1 antibody;11 beta HSD1 antibody;11 beta hydroxysteroid dehydrogenase 1 antibody;11 DH antibody;11-beta hydroxysteroid dehydrogenase, type 1 antibody;11-beta-HSD1 antibody;11-beta-hydroxysteroid dehydrogenase 1 antibody;11-DH antibody;11DH antibody;Corticosteroid 11 beta dehydrogenase isozyme 1 antibody;Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody;CORTRD2 antibody;DHI1_HUMAN antibody;HDL antibody;HSD 11 antibody;HSD11 antibody;HSD11B antibody;HSD11B1 antibody;HSD11L antibody;Hydroxysteroid (11 beta) dehydrogenase antibody;Hydroxysteroid (11 beta) dehydrogenase 1 antibody;MGC13539 antibody;SDR26C1 antibody;short chain dehydrogenase/reductase family 26C, member 1 antibody

SEQUENCE SIMILARITIES

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

TISSUE SPECIFICITY

Widely expressed. Highest expression in liver.

POST-TRANSLATIONAL MODIFICATION

Glycosylated.

SUBCELLULAR LOCATION

Endoplasmic reticulum, Membrane.

FUNCTION

HSD11B1(Corticosteroid 11-beta-dehydrogenase isozyme 1) is also named as HSD11, HSD11L,11-DH and 11-beta-HSD1.It is a microsomal enzyme, which acts mainly as a NADP(H)- dependent reductase converting inactive cortisone (E) to active cortisol (F), thus regulating intracellular F access to glucocorticoid receptor. This enzyme is widely expressed not only in liver and adipose tissue, but also in adrenal, ovary and decidua.Western blot analysis in human liver, using a specific11-beta-HSD1 antibody, showed two bands at approximately 34 and 68 kDa confrming the dimeric nature of 11-beta-HSD1 in liver and In omental adipose tissue, an additional band of 50 kDa was strongly expressed.