HSD3B1 Rabbit Polyclonal Antibody (HA500082)
Catalog# HA500082
Rabbit Polyclonal to HSD3B1
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WB
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IF-Cell
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IHC-P
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Human
Specifications
Product Type
Rabbit polyclonal primary
Product Name
HSD3B1 Rabbit Polyclonal Antibody (HA500082)
Immunogen
Synthetic peptide within human hsd3b1 aa 320-373.
Host
Rabbit
Positive Control
Human placenta tissue lysates, MCF-7, LOVO, human placenta tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:2,000-1:5,000
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IF-Cell
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1:50-1:200
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IHC-P
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1:100-1:500
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
42 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
HSD3B1
SYNONYMS
3 beta and steroid delta isomerase 1 antibody;3 beta and steroid hydroxy delta 5 steroid dehydrogenase antibody;3 beta HSD I antibody;3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I antibody;3-beta-HSD I antibody;3-beta-hydroxy-5-ene steroid dehydrogenase antibody;3BETAHSD antibody;3BH antibody;3BHS1_HUMAN antibody;3BHSD antibody;Delta-5-3-ketosteroid isomerase antibody;HGNC:5217 antibody;HSD3B antibody;HSD3B1 antibody;HSDB3 antibody;HSDB3A antibody;Hydroxy delta 5 steroid dehydrogenase 3 beta and steroid delta isomerase 1 antibody;Hydroxy delta 5 steroid dehydrogenase antibody;Progesterone reductase antibody;SDR11E1 antibody;Steroid Delta-isomerase antibody;trophoblast antigen antibody;Trophoblast antigen FDO161G antibody
SUBCELLULAR LOCATION
Endoplasmic reticulum, Membrane, Mitochondrion.
FUNCTION
bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta5-steroid precursors to 3-oxo-Delta4-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Expected to use NAD+ as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity.
CITATIONS
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Tang, C., Jin, M., Ma, B., Cao, B., Lin, C., Xu, S., Li, J., & Xu, Q.
RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy
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WB
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Human
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Citation
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Xue Qian,et al
Hexavalent chromium reduces testosterone levels by impairing lipophagy and disrupting lipid metabolism homeostasis: based on a metabolomic analysis
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WB
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Mouse
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Citation
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