HSP60 Mouse Monoclonal Antibody [9-49] (M1007-9)

UNIPROT #

P10809

PROTEIN NAME

HSP60

SYNONYMS

60 kDa chaperonin antibody;60 kDa heat shock protein, mitochondrial antibody;CH60_HUMAN antibody;Chaperonin 60 antibody;Chaperonin, 60-KD antibody;CPN60 antibody;fa04a05 antibody;GROEL antibody;heat shock 60kDa protein 1 (chaperonin) antibody;Heat shock protein 1 (chaperonin) antibody;Heat shock protein 60 antibody;Heat shock protein 65 antibody;heat shock protein family D (Hsp60) member 1 antibody;HLD4 antibody;Hsp 60 antibody;HSP 65 antibody;HSP-60 antibody;HSP60 antibody;HSP65 antibody;HSPD1 antibody;HuCHA60 antibody;Mitochondrial matrix protein P1 antibody;P60 lymphocyte protein antibody;short heat shock protein 60 Hsp60s1 antibody;SPG13 antibody

SEQUENCE SIMILARITIES

Belongs to the chaperonin (HSP60) family.

SUBCELLULAR LOCATION

Mitochondrion matrix

FUNCTION

HSP60, also known as chaperonins (Cpn), is a family of heat shock proteins originally sorted by their 60kDa molecular mass. They prevent misfolding of proteins during stressful situations such as high heat, by assisting protein folding. HSP60 belong to a large class of molecules that assist protein folding, called molecular chaperones. Newly made proteins usually must fold from a linear chain of amino acids into a three-dimensional tertiary structure. The energy to fold proteins is supplied by non-covalent interactions between the amino acid side chains of each protein, and by solvent effects. Most proteins spontaneously fold into their most stable three-dimensional conformation, which is usually also their functional conformation, but occasionally proteins mis-fold. Molecular chaperones catalyze protein refolding by accelerating partial unfolding of misfolded proteins, aided by energy supplied by the hydrolysis of adenosine triphosphate (ATP). Chaperonin proteins may also tag misfolded proteins to be degraded.