HSP90 Beta Mouse Monoclonal Antibody [2-1-G3] (EM21103)

UNIPROT #

P08238

PROTEIN NAME

HSP90 Beta

SYNONYMS

90 kda heat shock protein beta HSP90 beta antibody;D6S182 antibody;FLJ26984 antibody;Heat shock 84 kDa antibody;Heat shock 90kD protein 1, beta antibody;Heat shock 90kDa protein 1 beta antibody;Heat shock protein 90 alpha family class B member 1 antibody;Heat shock protein 90 kDa antibody;Heat shock protein 90kDa alpha (cytosolic) class B member 1 antibody;Heat shock protein 90kDa alpha family class B member 1 antibody;Heat shock protein beta antibody;Heat shock protein HSP 90 beta antibody;Heat shock protein HSP 90-beta antibody;HS90B_HUMAN antibody;HSP 84 antibody;HSP 90 antibody;HSP 90 b antibody;HSP 90b antibody;HSP84 antibody;HSP90 BETA antibody;hsp90ab1 antibody;HSP90B antibody;HSPC2 antibody;HSPCB antibody

SEQUENCE SIMILARITIES

Belongs to the heat shock protein 90 family.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).; ISGylated.; S-nitrosylated; negatively regulates the ATPase activity.; Phosphorylation at Tyr-301 by SRC is induced by lipopolysaccharide. Phosphorylation at Ser-226 and Ser-255 inhibits AHR interaction.; Methylated by SMYD2; facilitates dimerization and chaperone complex formation; promotes cancer cell proliferation.; Cleaved following oxidative stress resulting in HSP90AB1 protein radicals formation; disrupts the chaperoning function and the degradation of its client proteins.

SUBCELLULAR LOCATION

Cytoplasm

FUNCTION

Heat shock protein HSP 90-beta also called HSP90beta is a protein that in humans is encoded by the HSP90AB1 gene. HSP90AB1 is a molecular chaperone. Chaperones are proteins that bind to other proteins, thereby stabilizing them in an ATP-dependent manner. Chaperones stabilize new proteins during translation, mature proteins which are partially unstable but also proteins that have become partially denatured due to various kinds of cellular stress. In case proper folding or refolding is impossible, HSPs mediate protein degradation. They also have specialized functions, such as intracellular transport into organelles.