Human CXCL1/GRO alpha enzyme-linked immunoassay kit(EH0054)

UNIPROT #

P09341

PROTEIN NAME

CXCL1/GRO alpha

SYNONYMS

Growth-regulated alpha protein C-X-C motif chemokine 1 GRO-alpha(1-73) Melanoma growth stimulatory activity (MGSA) Neutrophil-activating protein 3 (NAP-3) GRO-alpha(4-73) GRO-alpha(5-73) GRO-alpha(6-73) CXCL1 GRO GRO1 GROA MGSA SCYB1

FUNCTION

CXCL1/GRO alpha, also known as KC in mouse and CINC-1 in rat, is a member of the CXC family of chemokines. Human CXCL1/GRO alpha is 107 amino acids (aa) in length with a predicted molecular weight of 11 kDa. The mouse and rat orthologs share 57% and 59% amino acid sequence identity with the human protein, respectively. Genome-wide analysis suggests that the protein encoded by the mouse Cxcl3 gene is homologous to human CXCL1/GRO alpha protein. Human CXCL1/GRO alpha can be cleaved into three isoforms CXCL1/GRO alpha (aa 4-73), CXCL1/GRO alpha (aa 5-73), and CXCL1/GRO alpha (aa 6-73) which show higher activity than the full length protein. CXCL1/GRO alpha is secreted by mast cells and macrophages whereupon it acts as a chemoattractant for neutrophils.