Human MMP-9 Recombinant Rabbit Monoclonal Antibody [PSH04-62] (HA722162)

UNIPROT #

P14780

PROTEIN NAME

Human MMP-9

SYNONYMS

82 kDa matrix metalloproteinase-9 antibody;92 kDa gelatinase antibody;92 kDa type IV collagenase antibody;CLG 4B antibody;CLG4B antibody;Collagenase Type 4 beta antibody;Collagenase type IV 92 KD antibody;EC 3.4.24.35 antibody;Gelatinase 92 KD antibody;Gelatinase B antibody;Gelatinase beta antibody;GelatinaseB antibody;GELB antibody;Macrophage gelatinase antibody;MANDP2 antibody;Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) antibody;Matrix Metalloproteinase 9 antibody;MMP 9 antibody;MMP-9 antibody;MMP9 antibody;MMP9_HUMAN antibody;Type V collagenase antibody

SUBCELLULAR LOCATION

Secreted, extracellular space, extracellular matrix.

FUNCTION

Matrix metalloproteinase-9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, angiogenesis, bone development, wound healing, cell migration, learning and memory, as well as in pathological processes, such as arthritis, intracerebral hemorrhage, and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens and other extracellular matrix proteins. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Thrombospondins, intervertebral disc proteins, regulate interaction with matrix metalloproteinases (MMPs) 2 and 9, which are key effectors of ECM remodeling.