IGF1 Recombinant Rabbit Monoclonal Antibody [JE30-01] (HA722527)

UNIPROT #

P05019

PROTEIN NAME

IGF1

SYNONYMS

IBP1 antibody;IGF I antibody;IGF IA antibody;IGF IB antibody;IGF-I antibody;Igf1 antibody;IGF1_HUMAN antibody;IGF1A antibody;IGFI antibody;IGFIA antibody;Insulin like growth factor 1 (somatomedin C) antibody;Insulin like growth factor 1 antibody;Insulin like growth factor IA antibody;Insulin like growth factor IB antibody;Insulin-like growth factor I antibody;Mechano growth factor antibody;MGF antibody;OTTHUMP00000195080 antibody;OTTHUMP00000195081 antibody;OTTHUMP00000195082 antibody;OTTHUMP00000195083 antibody;OTTHUMP00000195084 antibody;Somatomedia C antibody;Somatomedin C antibody;Somatomedin-C antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults. In the 1950s IGF-1 was called "sulfation factor" because it stimulated sulfation of cartilage in vitro, and in the 1970s due to its effects it was termed "nonsuppressible insulin-like activity" (NSILA). IGF-1 is a protein that in humans is encoded by the IGF1 gene. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7,649 daltons. In dogs, an ancient mutation in IGF1 is the primary cause of the toy phenotype. IGF-1 is produced primarily by the liver. Production is stimulated by growth hormone (GH). Most of IGF-1 is bound to one of 6 binding proteins (IGF-BP). IGFBP-1 is regulated by insulin. IGF-1 is produced throughout life; the highest rates of IGF-1 production occur during the pubertal growth spurt. The lowest levels occur in infancy and old age. Low IGF-1 levels are associated with cardiovascular disease, while high GF-1 levels are associated with cancer. Mid-range IGF-1 levels are associated with the lowest mortality.