IKK alpha Rabbit Polyclonal Antibody (ER30911)

UNIPROT #

O15111

PROTEIN NAME

IKK alpha

SYNONYMS

chuk antibody;CHUK1 antibody;Conserved Helix Loop Helix Ubiquitous Kinase antibody;Conserved helix loop ubiquitous kinase antibody;Conserved helix-loop-helix ubiquitous kinase antibody;I Kappa B Kinase 1 antibody;I Kappa B Kinase Alpha antibody;I-kappa-B kinase 1 antibody;I-kappa-B kinase alpha antibody;IkappaB kinase antibody;IkB kinase alpha subunit antibody;IkBKA antibody;IKK 1 antibody;IKK A antibody;IKK a kinase antibody;IKK-A antibody;IKK-alpha antibody;IKK1 antibody;IKKA antibody;IKKA_HUMAN antibody;Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibody;Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibody;Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody;NFKBIKA antibody;Nuclear Factor Kappa B Inhibitor Kinase Alpha antibody;Nuclear factor NF kappa B inhibitor kinase alpha antibody;Nuclear factor NF-kappa-B inhibitor kinase alpha antibody;Nuclear factor NFkappaB inhibitor kinase alpha antibody;Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibody;TCF-16 antibody;TCF16 antibody;Transcription factor 16 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.

TISSUE SPECIFICITY

Widely expressed.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.; (Microbial infection) Acetylation of Thr-179 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B signaling pathway.

SUBCELLULAR LOCATION

Cytoplasm, nucleus.

FUNCTION

Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation. Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer. Mutations in IKK-α in humans have been linked to lethal fetal malformations. The phenotype of these mutant fetuses is similar to the mouse IKK-α null phenotype, and is characterized by shiny, thickened skin and truncated limbs. Decreased IKK-α activity has been reported in a large percentage of human squamous cell carcinomas, and restoring IKK-α in mouse models of skin cancer has been shown to have an anti-tumorigenic effect.