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IL-10RA Rabbit Polyclonal Antibody (HA500251)

Price: Regular price $315.00

Volume

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Catalog# HA500251

Rabbit Polyclonal to IL-10RA

Tested for

  • WB

  • IHC-P

  • IF-Cell

Reacts with

  • Human

Safety datasheet

Select your chosen country/region

Specifications

Product Type

Rabbit polyclonal primary

Product Name

IL-10RA Rabbit Polyclonal Antibody (HA500251)

Immunogen

Synthetic peptide within human il-10ra aa 491-540/578.

Host

Rabbit

Positive Control

Daudi cell lysates, Jurkat cell lysate, THP-1 cell lysate, MCF-7 cell lysate, human tonsil tissue, SiHa.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071347

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:200-1:1,000

  • IF-Cell

  • 1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

63 kDa

Isotype

IgG

TARGET

UNIPROT #

Q13651

PROTEIN NAME

IL-10RA

SYNONYMS

CD210 antibody;CDw210a antibody;CDw210a antigen antibody;HIL 10R antibody;HIL10R antibody;I10R1_HUMAN antibody;IL 10R 1 antibody;IL 10R A antibody;IL 10R antibody;IL 10R1 antibody;IL-10 receptor subunit alpha antibody;IL-10R subunit 1 antibody;IL-10R subunit alpha antibody;IL-10R1 antibody;IL-10RA antibody;IL10R antibody;IL10R1 antibody;IL10RA antibody;Interleukin 10 receptor alpha antibody;Interleukin 10 receptor alpha chain antibody;Interleukin-10 receptor subunit 1 antibody;Interleukin-10 receptor subunit alpha antibody

SUBCELLULAR LOCATION

Cytoplasm, Cell membrane.

FUNCTION

Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy.

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