IL-21R Rabbit Polyclonal Antibody (HA500290)

UNIPROT #

Q9HBE5

PROTEIN NAME

IL-21R

SYNONYMS

CD360 antibody;IL 21R antibody;IL-21 receptor antibody;IL-21R antibody;IL21 receptor antibody;IL21R antibody;IL21R_HUMAN antibody;Interleukin 21 receptor antibody;Interleukin-21 receptor antibody;MGC10967 antibody;NILR antibody;Novel interleukin receptor antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.