IL-23 Recombinant Rabbit Monoclonal Antibody [JE38-99] (HA721037)

UNIPROT #

Q9NPF7

PROTEIN NAME

IL-23

SYNONYMS

IL 23 A antibody;IL 23 antibody;IL 23 subunit alpha antibody;IL 23A antibody;IL 23p19 antibody;IL-23 subunit alpha antibody;IL-23-A antibody;IL-23p19 antibody;IL12B antibody;IL23 antibody;Il23a antibody;IL23A_HUMAN antibody;IL23P19 antibody;interleukin 12B antibody;Interleukin 23 alpha subunit p19 antibody;Interleukin 23 p19 subunit antibody;interleukin 23 subunit alpha antibody;interleukin 23 subunit p19 antibody;interleukin six, G CSF related factor antibody;Interleukin-23 subunit alpha antibody;Interleukin-23 subunit p19 antibody;JKA3 induced upon T cell activation antibody;MGC79388 antibody;P19 antibody;SGRF antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.