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IL-7 Rabbit Polyclonal Antibody (HA500171)

Price: Regular price $315.00

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Catalog# HA500171

Rabbit Polyclonal to IL-7

Tested for

  • WB

  • IF-Cell

  • IHC-P

Reacts with

  • Human

Specifications

Product Type

Rabbit polyclonal primary

Product Name

IL-7 Rabbit Polyclonal Antibody (HA500171)

Immunogen

Synthetic peptide within human il-7 aa 1-50.

Host

Rabbit

Positive Control

SHSY5Y cell lysate, HepG2 cell lysate, PANC-1, SH-SY5Y, SiHa, human tonsil tissue, human spleen tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071268

APPLICATION DILUTION

  • WB

  • 1:500

  • IF-Cell

  • 1:50-1:100

  • IHC-P

  • 1:200-1:500

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

20/15 kDa

Isotype

IgG

TARGET

UNIPROT #

P13232

PROTEIN NAME

IL-7

SYNONYMS

IL 7 antibody;IL-7 antibody;Il7 antibody;IL7_HUMAN antibody;Interleukin 7 antibody;Interleukin-7 antibody;LP-1 antibody;Lymphopoietin 1 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Interleukin-7 (IL-7) was originally described as a factor capable of inducing in vitro proliferation of pre-B cells from marrow cultures. The IL-7 gene encodes a protein 177 amino acids in length. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor-specific chain and the IL-2 receptor γ chain common to the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors. IL-7 stimulation leads to the activation of Janus tyrosine kinase family members JAK1 and JAK3. Other studies have shown that in T cells, the IL-7 receptor-specific chain associates with the Src kinases family Lck and Fyn. IL-7 induces phosphorylation of insulin receptor substrate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2), originally called 4PS.

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