IL-7R alpha Rabbit Polyclonal Antibody (ER1706-68)

UNIPROT #

P16871

PROTEIN NAME

IL-7R-alpha

SYNONYMS

CD 127 antibody;CD127 antibody;CD127 antigen antibody;CDw127 antibody;IL 7R alpha antibody;IL 7R antibody;IL-7 receptor subunit alpha antibody;IL-7R subunit alpha antibody;IL-7R-alpha antibody;IL-7RA antibody;IL7R antibody;IL7RA antibody;IL7RA_HUMAN antibody;IL7Ralpha antibody;ILRA antibody;Interleukin 7 receptor alpha chain antibody;Interleukin 7 receptor antibody;Interleukin 7 receptor isoform H5 6 antibody;Interleukin-7 receptor subunit alpha antibody

SEQUENCE SIMILARITIES

Belongs to the type I cytokine receptor family. Type 4 subfamily.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.

SUBCELLULAR LOCATION

Membrane. Secreted.

FUNCTION

The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-α (CD127) and common-γ chain receptor (CD132). The common-γ chain receptors is shared with various cytokines, including interleukin-2, -4, -9, and -15. Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others. Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination [citation needed]. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation [citation needed]. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).