IL-8 Rabbit Polyclonal Antibody (ER1706-67)

UNIPROT #

P10145

PROTEIN NAME

IL-8

SYNONYMS

(Ala-IL-8)77 antibody;(Ser-IL-8)72 antibody;9E3 antibody;Beta thromboglobulin like protein antibody;C-X-C motif chemokine 8 antibody;CEF-4 antibody;chemokine, CXC motif, ligand 8 antibody;CXCL8 antibody;Emoctakin antibody;GCP-1 antibody;GCP/IL-8 protein I antibody;GCP/IL-8 protein II antibody;GCP/IL-8 protein III antibody;GCP/IL-8 protein IV antibody;GCP/IL-8 protein V antibody;GCP/IL-8 protein VI antibody;GCP1 antibody;Granulocyte chemotactic protein 1 antibody;IL-8 antibody;IL-8(1-77) antibody;IL-8(9-77) antibody;IL8 antibody;IL8/NAP1 form I antibody;IL8/NAP1 form II antibody;IL8/NAP1 form III antibody;IL8/NAP1 form IV antibody;IL8/NAP1 form V antibody;IL8/NAP1 form VI antibody;IL8_HUMAN antibody;Inteleukin 8 antibody;LECT antibody;LUCT antibody;Lymphocyte-derived neutrophil-activating factor antibody;LYNAP antibody;MDNCF antibody;MDNCF-b antibody;MDNCF-c antibody;MONAP antibody;Monocyte-derived neutrophil chemotactic factor antibody;Monocyte-derived neutrophil-activating peptide antibody;NAF antibody;NAP-1 antibody;NAP1 antibody;Neutrophil activating peptide 1 antibody;Neutrophil activating protein 1 antibody;Neutrophil-activating factor antibody;Neutrophil-activating protein 1 antibody;Protein 3 10C antibody;Protein 3-10C antibody;SCYB8 antibody;Small inducible cytokine subfamily B member 8 antibody;T cell chemotactic factor antibody;T-cell chemotactic factor antibody;TSG1 antibody

SEQUENCE SIMILARITIES

Belongs to the intercrine alpha (chemokine CxC) family.

POST-TRANSLATIONAL MODIFICATION

Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.; Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. IL-8, also known as neutrophil chemotactic factor, has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived. IL-8 is also known to be a potent promoter of angiogenesis. In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis (e.g. histamine release), and the respiratory burst. IL-8 can be secreted by any cells with toll-like receptors that are involved in the innate immune response and has been demonstrated to be a signatory chemokine of CR2+ naive T cells, also known as recent thymic emigrants. Usually, it is the macrophages that see an antigen first, and thus are the first cells to release IL-8 to recruit other cells. Both monomer and homodimer forms of IL-8 have been reported to be potent inducers of the chemokine receptors CXCR1 and CXCR2. The homodimer is more potent, but methylation of Leu25 can block the activity of homodimers.