ST2 Rabbit Polyclonal Antibody (0902-2)

UNIPROT #

Q01638

PROTEIN NAME

ST2

SYNONYMS

DER-4 antibody;DER4 antibody;FIT 1 antibody;Growth stimulation expressed antibody;homolog of mouse growth stimulation-expressed antibody;Il1rl1 antibody;IL33R antibody;ILRL1_HUMAN antibody;Interleukin 1 receptor like 1 antibody;interleukin 1 receptor related protein antibody;Interleukin-1 receptor-like 1 antibody;Protein ST2 antibody;ST2 antibody;ST2L antibody;ST2V antibody;T1 antibody;T1 protein antibody

SEQUENCE SIMILARITIES

Belongs to the interleukin-1 receptor family.

TISSUE SPECIFICITY

Predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines. Isoform A is expressed in brain astrocytes and microglia. Isoform B is expressed in brain endothelial cells.

DEVELOPMENTAL STAGE

Expressed first in the fetal liver and then in lung and hematopoietic tissues.

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.