IL-6 Mouse Monoclonal Antibody [1-6] (EM1701-45)
Catalog# EM1701-45
Mouse Monoclonal to IL-6
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WB
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IF-Cell
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Mouse
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Rat
Specifications
Product Type
Mouse monoclonal primary
Product Name
IL-6 Mouse Monoclonal Antibody [1-6] (EM1701-45)
Immunogen
Recombinant protein within mouse il-6 aa 1-211 / 211.
Host
Mouse
Positive Control
Recombinant protein lysates, EL4.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
1-6
RRID
APPLICATION DILUTION
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WB
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1:500-1:2,000
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IF-Cell
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1:50-1:1,000
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
2ug/ul
Purification
Protein G affinity purified.
Molecular Weight
24 kDa
Isotype
IgG2b
TARGET
UNIPROT #
PROTEIN NAME
IL-6
SYNONYMS
Interleukin BSF 2 antibody;B cell differentiation factor antibody;B cell stimulatory factor 2 antibody;B-cell stimulatory factor 2 antibody;BSF 2 antibody;BSF-2 antibody;BSF2 antibody;CDF antibody;CTL differentiation factor antibody;Hepatocyte stimulatory factor antibody;HGF antibody;HSF antibody;Hybridoma growth factor antibody;Hybridoma growth factor Interferon beta-2 antibody;IFN-beta-2 antibody;IFNB2 antibody;IL 6 antibody;IL-6 antibody;IL6 antibody;IL6_HUMAN antibody;Interferon beta 2 antibody;Interferon beta-2 antibody;Interleukin 6 antibody;Interleukin 6 (interferon beta 2) antibody;Interleukin BSF 2 antibody;Interleukin-6 antibody
SEQUENCE SIMILARITIES
Belongs to the IL-6 superfamily.
POST-TRANSLATIONAL MODIFICATION
N- and O-glycosylated.
SUBCELLULAR LOCATION
Secreted.
FUNCTION
Interleukin-6, or IL-6, is a multifunctional protein, 212 amino acids in length, that plays critical roles in host defense, immune response and hematopoiesis. IL-6 is constitutively expressed by epidermal Langerhans cells and its expression is induced in stimulated keratinocytes. IL-6, IL-1β and TNFα act as endogenous pyrogens, regulating the fever response to bacterial invasion. The IL-6 receptor is a trimeric complex composed of an IL-6-specific α chain and a homodimer of the gp130 glycoprotein common to the IL-6, IL-11, CNTF, OSM and LIF receptors. Stimulation with IL-6 leads to gp130 homodimerization and the activation of associated kinases JAK1 and JAK2. Once activated, JAK1 and JAK2 phosphorylate Stat3, causing its nuclear translocation and transcription of Stat3-responsive genes. IL-6 has also been shown to activate the Ras/MAP kinase pathway, which regulates NFIL6 transcription.
CITATIONS
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Yinhe Sikong,et al
Bacteroides thetaiotaomicron and its inactivated bacteria ameliorate colitis by inhibiting macrophage activation
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WB
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Mouse
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Citation
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Alveolar macrophage-derived progranulin mediated pro-inflammatory Il-6 expression via regulating Creb1 in silicosis model
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WB
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Mouse
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Citation
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ABCA1 deficiency-mediated glomerular cholesterol accumulation exacerbates glomerular endothelial injury and dysfunction in diabetic kidney disease
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IF
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Mouse
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Citation
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Deng, L., Zhang, X., Xiang, X., Xiong, R., Xiao, D., Chen, Z., Liu, K., & Feng, G.
NANOG Promotes Cell Proliferation, Invasion, and Stemness via IL-6/STAT3 Signaling in Esophageal Squamous Carcinoma
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WB
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Human
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Citation
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Wang Qian,et al
Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation
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IF
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Rat
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Citation
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Shi Ying,et al
Empagliflozin protects against heart failure with preserved ejection fraction partly by inhibiting the senescence-associated STAT1-STING axis
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WB
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Mouse
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Rat
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Citation
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Single-cell RNA sequencing deciphers the mechanism of sepsis-induced liver injury and the therapeutic effects of artesunate
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WB
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Mouse
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Citation
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Ruiqin Hu,et al
bmp10 maintains cardiac function by regulating iron homeostasis
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WB
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Zebrafish
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Citation
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Wei Shi,et al
Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells
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WB
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Mouse
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Citation
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Haoyan Wu,et al
A Multifunctional miRNA Delivery System Based on Tetrahedral Framework Nucleic Acids for Regulating Inflammatory Periodontal Ligament Stem Cells and Attenuating Periodontitis Bone Loss
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WB
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Rat
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Citation
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Su JH, Wu GP, Peng X, et al
Neuroprotective Effects of an N-Salicyloyl Tryptamine Derivative against Cerebral Ischemia/Reperfusion Injury
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WB
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Mouse
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Citation
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Huang Jie,et al
DP7-C/mir-26a system promotes bone regeneration by remodeling the osteogenic immune microenvironment
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WB
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Rat
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Citation
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Mi Zhang,et al
Study on the Mechanism of Guizhi Fuling Decoction in Treating Hyperlipidemia Based on Network Pharmacology and Experimental Methods
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WB
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Rat
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Citation
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Mi Ai,et al
Hepatoprotective efficacy and interventional mechanism of panaxanediol saponins component in high-fat diet-induced NAFLD mice
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WB
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Mouse
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Citation
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Chen Junhui,et al
Single-cell transcriptomics reveals the ameliorative effect of Rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation
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WB
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Mouse
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Citation
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Xia, Y., Luo, Q., Huang, C., Shi, L., Jahangir, A., Pan, T., Wei, X., He, J., Liu, W., Shi, R., Geng, Y., Fang, J., Tang, L., Guo, H., Ouyang, P., & Chen, Z.
Ferric citrate-induced colonic mucosal damage associated with oxidative stress, inflammation responses, apoptosis, and the changes of gut microbial composition
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WB
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Mouse
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Citation
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