Insulin Receptor R Recombinant Rabbit Monoclonal Antibody [JM22-38] (ET1705-22)
Catalog# ET1705-22
Rabbit Monoclonal to Insulin Receptor R
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WB
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IHC-P
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Human
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Mouse
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Rat
Specifications
Product Type
Recombinant Rabbit monoclonal primary
Product Name
Insulin Receptor R Recombinant Rabbit Monoclonal Antibody [JM22-38] (ET1705-22)
Immunogen
Synthetic peptide within human insulin receptor r aa 12-61 / 1,297.
Host
Rabbit
Positive Control
Human liver carcinoma tissue, human colon carcinoma tissue, human kidney tissue, mouse testis tissue, mouse kidney tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
JM22-38
RRID
APPLICATION DILUTION
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WB
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1:500
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IHC-P
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1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 144 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
Insulin Receptor R
SYNONYMS
INSRR antibody;INSRR_HUMAN antibody;Insulin receptor related receptor precursor antibody;Insulin receptor-related protein alpha chain antibody;Insulin receptor-related protein beta chain antibody;insulin receptor-related receptor antibody;IR R antibody;IR related receptor antibody;IR-related receptor antibody;IRR antibody;Sir r antibody;Sirr antibody
SEQUENCE SIMILARITIES
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
POST-TRANSLATIONAL MODIFICATION
Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5.
SUBCELLULAR LOCATION
Membrane.
FUNCTION
Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene. Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
CITATIONS
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Li, J., Mao, Y. S., Chen, F., Xia, D. X., & Zhao, T. Q.
Palmitic acid up regulates Gal-3 and induces insulin resistance in macrophages by mediating the balance between KLF4 and NF-κB
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Guo Yingxue,et al
Integrated network pharmacological analysis revealed that Smilax glabra Roxb. alleviates IMQ-induced psoriatic skin inflammation through regulating T cell immune response
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WB
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Mouse
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Citation
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