Integrin alpha V Recombinant Rabbit Monoclonal Antibody [SC56-07] (ET1610-15)

UNIPROT #

P06756

PROTEIN NAME

Integrin alpha V

SYNONYMS

CD51 antibody;Integrin alpha-V light chain antibody;integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) antibody;Integrin, alpha V antibody;Integrin, beta 6 antibody;ITAV_HUMAN antibody;ITGAV antibody;ITGB6 antibody;Vitronectin receptor subunit alpha antibody

SEQUENCE SIMILARITIES

Belongs to the integrin alpha chain family.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands, such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.