Integrin beta 3 Recombinant Rabbit Monoclonal Antibody [JE22-64] (ET7110-61)

UNIPROT #

P05106

PROTEIN NAME

Integrin beta 3

SYNONYMS

BDPLT16 antibody;BDPLT2 antibody;CD 61 antibody;CD61 antibody;CD61 antigen antibody;GP3A antibody;GPIIIa antibody;GT antibody;HPA 1 antibody;HPA 4 antibody;Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody;Integrin beta chain beta 3 antibody;Integrin beta-3 antibody;ITB3_HUMAN antibody;ITG B3 antibody;ITGB 3 antibody;ITGB3 antibody;NAIT antibody;platelet fibrinogen receptor antibody;Platelet fibrinogen receptor beta subunit antibody;Platelet fibrinogen receptor, beta subunit antibody;Platelet glycoprotein IIIa antibody;Platelet glycoprotein IIIa precursor antibody;Platelet membrane glycoprotein IIIa antibody;PTP antibody

SEQUENCE SIMILARITIES

Belongs to the integrin beta chain family.

TISSUE SPECIFICITY

Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Probably involved in outside-in signaling. A peptide (AA 740-762) is capable of binding GRB2 only when both Tyr-773 and Tyr-785 are phosphorylated. Phosphorylation of Thr-779 inhibits SHC binding.

SUBCELLULAR LOCATION

Cell membrane, lamellipodium membrane, postsynaptic cell membrane, focal adhesion, synapse.

FUNCTION

Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets. ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition.