ITPR2 Rabbit Polyclonal Antibody (ER1803-65)

UNIPROT #

Q14571

PROTEIN NAME

ITPR2

SYNONYMS

4 antibody;5-trisphosphate receptor antibody;Inositol 1 4 5 trisphosphate receptor type 2 antibody;Inositol 1,4,5-trisphosphate receptor type 2 antibody;Inositol 145 trisphosphate receptor type 2 antibody;InsP3 R2 antibody;InsP3R2 antibody;IP3 R2 antibody;IP3 receptor antibody;IP3 receptor isoform 2 antibody;IP3R 2 antibody;IP3R2 antibody;ITPR 2 antibody;Itpr2 antibody;ITPR2_HUMAN antibody;Type 2 inositol 1 4 5 trisphosphate receptor antibody;Type 2 inositol 1 antibody;Type 2 inositol 145 trisphosphate receptor antibody;Type 2 InsP3 receptor antibody

SEQUENCE SIMILARITIES

Belongs to the InsP3 receptor family.

TISSUE SPECIFICITY

Isoform Short is found in skeletal muscle and heart.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane.

FUNCTION

The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.