Skip to content

Contact

(857) 353-6600

orders@huabio.com

JNK2 Recombinant Rabbit Monoclonal Antibody [SC05-85] (ET1610-11)

Price: Regular price $385.00

Volume

Bulk Order Quote   |   Customization Request

Catalog# ET1610-11

Rabbit Monoclonal to JNK2

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • IP

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

Select your chosen country/region

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

JNK2 Recombinant Rabbit Monoclonal Antibody [SC05-85] (ET1610-11)

Immunogen

Synthetic peptide within human jnk2 aa 341-394 / 424.

Host

Rabbit

Positive Control

SHG-44 cell lysates, Hela, MCF-7, SHG-44, mouse brain tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SC05-85

RRID

AB_3069894

APPLICATION DILUTION

  • WB

  • 1:1,000-1:5,000

  • IF-Cell

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:50-1:100

  • IP

  • Use at an assay dependent concentration.

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 48/44 kDa

Isotype

IgG

TARGET

UNIPROT #

P45984

PROTEIN NAME

JNK2

SYNONYMS

c Jun kinase 2 antibody;C Jun N terminal kinase 2 antibody;c-Jun N-terminal kinase 2 antibody;JNK 55 antibody;JNK-55 antibody;JNK2 alpha antibody;JNK2 antibody;JNK2 beta antibody;JNK2A antibody;JNK2alpha antibody;JNK2B antibody;JNK2BETA antibody;Jun kinase antibody;MAP kinase 9 antibody;MAPK 9 antibody;Mapk9 antibody;Mitogen activated protein kinase 9 antibody;Mitogen-activated protein kinase 9 antibody;MK09_HUMAN antibody;P54a antibody;p54aSAPK antibody;PRKM9 antibody;Protein kinase, mitogen-activated, 9 antibody;SAPK alpha antibody;SAPK antibody;SAPK1a antibody;Stress activated protein kinase 1a antibody;Stress-activated protein kinase JNK2 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

POST-TRANSLATIONAL MODIFICATION

Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1α1, JNK1β1, JNK2α1, JNK2β1, and JNK3α1, which represent the p46 isoforms, and JNK1α2, JNK1β2, JNK2α2, JNK2β2, and JNK3β2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38.

CITATIONS

  • Luo, P., Yan, H., Chen, X., Zhang, Y., Zhao, Z., Cao, J., Zhu, Y., Du, J., Xu, Z., Zhang, X., Zeng, S., Yang, B., Ma, S., & He, Q.

    s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide. Cell research, 30(9), 779–793.

Close (esc)

Popup

Use this popup to embed a mailing list sign up form. Alternatively use it as a simple call to action with a link to a product or a page.

Age verification

By clicking enter you are verifying that you are old enough to consume alcohol.

Enter

Search

Main menu

Your cart is currently empty.
Shop now