KLC1 Recombinant Rabbit Monoclonal Antibody [JE54-47] (ET7110-72)

UNIPROT #

Q07866

PROTEIN NAME

KLC1

SYNONYMS

Kinesin 2 60/70kDa antibody;Kinesin light chain 1 antibody;Kinesin2 antibody;KLC 1 antibody;KLC antibody;Klc1 antibody;KLC1_HUMAN antibody;KNS 2 antibody;KNS 2A antibody;KNS2 antibody;KNS2A antibody;Medulloblastoma antigen MU MB 2.50 antibody;MGC15245 antibody

SEQUENCE SIMILARITIES

Belongs to the kinesin light chain family.

TISSUE SPECIFICITY

Found in a variety of tissues. Mostly abundant in brain and spine.

SUBCELLULAR LOCATION

Cytoskeleton, growth cone, cytoplasmic vesicle.

FUNCTION

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named ""kinesin 2"", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.