Ku80 Recombinant Rabbit Monoclonal Antibody [SC06-14] (ET1610-40)

UNIPROT #

P13010

PROTEIN NAME

Ku80

SYNONYMS

86 kDa subunit of Ku antigen antibody;ATP dependent DNA helicase 2 subunit 2 antibody;ATP dependent DNA helicase II 80 kDa subunit antibody;ATP dependent DNA helicase II 86 Kd subunit antibody;ATP dependent DNA helicase II antibody;ATP-dependent DNA helicase 2 subunit 2 antibody;ATP-dependent DNA helicase II 80 kDa subunit antibody;CTC box binding factor 85 kDa antibody;CTC box-binding factor 85 kDa subunit antibody;CTC85 antibody;CTCBF antibody;DNA repair protein XRCC5 antibody;KARP 1 antibody;KARP1 antibody;Ku 80 antibody;Ku autoantigen 80kDa antibody;Ku80 antibody;Ku86 antibody;Ku86 autoantigen related protein 1 antibody;KUB 2 antibody;KUB2 antibody;Lupus Ku autoantigen protein p86 antibody;NFIV antibody;Nuclear factor IV antibody;Thyroid lupus autoantigen antibody;Thyroid-lupus autoantigen antibody;TLAA antibody;X ray repair complementing defective repair in Chinese hamster cells 5 (double strand break rejoining) antibody;X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) antibody;X-ray repair cross-complementing protein 5 antibody;Xray repair complementing defective repair in Chinese hamster cells 5 antibody;XRCC 5 antibody;XRCC5 antibody;XRCC5_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the ku80 family.

DEVELOPMENTAL STAGE

Expression increases during promyelocyte differentiation.

POST-TRANSLATIONAL MODIFICATION

ADP-ribosylated by PARP3.; Phosphorylated on serine residues. Phosphorylation by PRKDC may enhance helicase activity.; Sumoylated.; Ubiquitinated by RNF8 via 'Lys-48'-linked ubiquitination following DNA damage, leading to its degradation and removal from DNA damage sites. Ubiquitinated by RNF138, leading to remove the Ku complex from DNA breaks.

SUBCELLULAR LOCATION

Nucleus, Chromosome.

FUNCTION

The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (p70) and Ku-86 (p86) which is also known by the synonym Ku-80 or (p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters. A Ku-related protein designated the enhancer 1 binding factor (E1BF), composed of two subunits, has been identified as a positive regulator of RNA polymerase I transcription initiation.