Lamin B1 Rabbit Polyclonal Antibody (R1508-1)
Catalog# R1508-1
Rabbit Polyclonal to Lamin B1
-
WB
-
Human
-
Rat
-
Mouse
Specifications
Product Type
Rabbit polyclonal primary
Product Name
Lamin B1 Rabbit Polyclonal Antibody (R1508-1)
Immunogen
Synthetic peptide within human lamin b1 aa 1-50 / 586.
Host
Rabbit
Positive Control
Jurkat cell lysate, MCF-7 cell lysate, PC12 cell lysate, Wild-type Hela whole cell lysate.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
-
WB
-
1:1,000
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 66 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
Lamin B1
SYNONYMS
ADLD antibody;lamin B1 antibody;Lamin-B1 antibody;LMN antibody;LMN2 antibody;LMNB antibody;Lmnb1 antibody;LMNB1_HUMAN antibody;MGC111419 antibody;OTTHUMP00000159218 antibody
SEQUENCE SIMILARITIES
Belongs to the intermediate filament family.
POST-TRANSLATIONAL MODIFICATION
B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
SUBCELLULAR LOCATION
Intermediate filament, Nucleus.
FUNCTION
Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Lamin B, along with heterochromatin, is anchored to the inner surface of the nuclear membrane by the lamin B receptor. LMNB1 has been shown to interact with Thymopoietin.
CITATIONS
-
Shui Bo Xu,et al
KPNA3 regulates histone locus body formation by modulating condensation and nuclear import of NPAT
-
WB
-
Human
-
Citation
-
-
Yong-xia Fang,et al
Glutamine Promotes Porcine Intestinal Epithelial Cell Proliferation through the Wnt/β-Catenin Pathway
-
WB
-
Human
-
Citation
-
-
Huanhuan Lou,et al
Protocol for transformation-free genome editing in plants using RNA virus vectors for CRISPR-Cas delivery
-
WB
-
Fish
-
Citation
-
-
Yan, H., Wu, W., Hu, Y., Li, J., Xu, J., Chen, X., Xu, Z., Yang, X., Yang, B., He, Q., & Luo, P.
Regorafenib inhibits EphA2 phosphorylation and leads to liver damage via the ERK/MDM2/p53 axis
-
WB
-
Mouse
-
Citation
-
-
Xu, J., Sun, S., Zhang, W., Dong, J., Huang, C., Wang, X., Jia, M., Yang, H., Wang, Y., Jiang, Y., Cao, L., & Huang, Z.
Irigenin inhibits glioblastoma progression through suppressing YAP/β-catenin signaling
-
WB
-
Human
-
Citation
-
-
Du Qian,et al
Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication
-
WB
-
Citation
-
Popup
Use this popup to embed a mailing list sign up form. Alternatively use it as a simple call to action with a link to a product or a page.
Age verification
By clicking enter you are verifying that you are old enough to consume alcohol.