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Lamin B1 Rabbit Polyclonal Antibody (R1508-1)

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Catalog# R1508-1

Rabbit Polyclonal to Lamin B1

Tested for

  • WB

Reacts with

  • Human

  • Rat

  • Mouse

Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Specifications

Product Type

Rabbit polyclonal primary

Product Name

Lamin B1 Rabbit Polyclonal Antibody (R1508-1)

Immunogen

Synthetic peptide within human lamin b1 aa 1-50 / 586.

Host

Rabbit

Positive Control

Jurkat cell lysate, MCF-7 cell lysate, PC12 cell lysate, Wild-type Hela whole cell lysate.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3073316

APPLICATION DILUTION

  • WB

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 66 kDa

Isotype

IgG

TARGET

UNIPROT #

P20700

PROTEIN NAME

Lamin B1

SYNONYMS

ADLD antibody;lamin B1 antibody;Lamin-B1 antibody;LMN antibody;LMN2 antibody;LMNB antibody;Lmnb1 antibody;LMNB1_HUMAN antibody;MGC111419 antibody;OTTHUMP00000159218 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

POST-TRANSLATIONAL MODIFICATION

B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

SUBCELLULAR LOCATION

Intermediate filament, Nucleus.

FUNCTION

Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Lamin B, along with heterochromatin, is anchored to the inner surface of the nuclear membrane by the lamin B receptor. LMNB1 has been shown to interact with Thymopoietin.

CITATIONS

  • Xu, J., Sun, S., Zhang, W., Dong, J., Huang, C., Wang, X., Jia, M., Yang, H., Wang, Y., Jiang, Y., Cao, L., & Huang, Z.

    Irigenin inhibits glioblastoma progression through suppressing YAP/β-catenin signaling

  • Huanhuan Lou,et al

    Protocol for transformation-free genome editing in plants using RNA virus vectors for CRISPR-Cas delivery

  • Yan, H., Wu, W., Hu, Y., Li, J., Xu, J., Chen, X., Xu, Z., Yang, X., Yang, B., He, Q., & Luo, P.

    Regorafenib inhibits EphA2 phosphorylation and leads to liver damage via the ERK/MDM2/p53 axis

  • Du Qian,et al

    Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication

  • Shui Bo Xu,et al

    KPNA3 regulates histone locus body formation by modulating condensation and nuclear import of NPAT

  • Yong-xia Fang,et al

    Glutamine Promotes Porcine Intestinal Epithelial Cell Proliferation through the Wnt/β-Catenin Pathway

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