LAMP2 Mouse Monoclonal Antibody [D3-D8-D3] (EM1901-62)

UNIPROT #

P13473

PROTEIN NAME

LAMP2

SYNONYMS

CD107 antigen like family member B antibody;CD107 antigen-like family member B antibody;CD107b antibody;LAMP 2 antibody;LAMP 2C antibody;LAMP-2 antibody;LAMP2 antibody;LAMP2_HUMAN antibody;LAMPB antibody;LGP 96 antibody;LGP110 antibody;LGP96 antibody;Lysosomal associated membrane protein 2 antibody;Lysosome associated membrane glycoprotein 2 antibody;Lysosome associated membrane protein 2 antibody;Lysosome-associated membrane glycoprotein 2 antibody;Lysosome-associated membrane protein 2 antibody;MAC3 antibody

SEQUENCE SIMILARITIES

Belongs to the LAMP family.

TISSUE SPECIFICITY

Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver. Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta.

POST-TRANSLATIONAL MODIFICATION

O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.

SUBCELLULAR LOCATION

Cell membrane, lysosome membrane, endosome membrane, autophagosome membrane.

FUNCTION

Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation. Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy. Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes. Required for normal degradation of the contents of autophagosomes. Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits. Is not required for efficient MHCII-mediated presentation of endogenous antigens.