LASS2 Mouse Monoclonal Antibody [B3-2] (M1006-6)

UNIPROT #

Q96G23

PROTEIN NAME

LASS2

SYNONYMS

Ceramide synthase 2 antibody;CerS 2 antibody;CerS2 antibody;CERS2_HUMAN antibody;FLJ10243 antibody;L3 antibody;LAG1 homolog ceramide synthase 2 antibody;LAG1 longevity assurance 2 antibody;LAG1 longevity assurance homolog 2 antibody;LASS 2 antibody;Longevity assurance (LAG1 S. cerevisiae) homolog 2 antibody;MGC987 antibody;SP 260 antibody;SP260 antibody;TMSG 1 antibody;TMSG1 antibody;Tumor metastasis suppressor antibody;Tumor metastasis suppressor gene 1 protein antibody;Tumor metastasis-suppressor gene 1 protein antibody

TISSUE SPECIFICITY

Expressed in kidney, liver, brain, heart, placenta and lung.

POST-TRANSLATIONAL MODIFICATION

Acetylated. Deacetylation by SIRT3 increases enzyme activity and promotes mitochondrial ceramide accumulation.; Phosphorylated at the C-terminus by CK2, leading to increase the ceramide synthase activity.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane

FUNCTION

The LAG1 gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. Expression of LASS2 in hepatocellular carcinoma cell lines suppresses the growth of cancer cells.The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.