LDHA Mouse Monoclonal Antibody [20-179] (M1007-7)

UNIPROT #

P00338

PROTEIN NAME

Lactate Dehydrogenase A

SYNONYMS

Cell proliferation-inducing gene 19 protein antibody;GSD11 antibody;L lactate dehydrogenase A chain antibody;L-lactate dehydrogenase A chain antibody;l7R2 antibody;Lactate dehydrogenase 1, A chain antibody;Lactate dehydrogenase A antibody;Lactate dehydrogenase A4 antibody;Lactate dehydrogenase M antibody;LDH A antibody;LDH M antibody;LDH muscle subunit antibody;LDH muscle subunit; M LDH antibody;LDH-A antibody;LDH-M antibody;LDH1 antibody;ldha antibody;LDHA_HUMAN antibody;LDHM antibody;OTTMUSP00000017774 antibody;PIG19 antibody;Proliferation-inducing gene 19 antibody;Renal carcinoma antigen NY-REN-59 antibody

SEQUENCE SIMILARITIES

Belongs to the LDH/MDH superfamily. LDH family.

POST-TRANSLATIONAL MODIFICATION

ISGylated.

SUBCELLULAR LOCATION

Cytoplasm

FUNCTION

Lactate dehydrogenase (LDH) is an enzyme present in a wide variety of organisms, including plants and animals. It catalyses the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. In medicine, LDH is often used as a marker of tissue breakdown as LDH is abundant in red blood cells and can function as a marker for hemolysis. In mammals, three types of LDH subunits (35 kDa) are encoded by the genes Ldh-A, Ldh-B, and Ldh-C. Lactate dehydrogenase B (LDH-B, heart subunit, LDH-H) is involved in the conversion of L-lactate and NAD to pryruvate and NADH and it is predominantly localized in the heart tissue. Similar to other LDH subunit, LDH-B is considered to be an important marker for germ cell tumor.