LEF1 Rabbit Polyclonal Antibody (HA500273)

UNIPROT #

Q9UJU2

PROTEIN NAME

LEF1

SYNONYMS

DKFZp586H0919 antibody;FLJ46390 antibody;LEF 1 antibody;LEF-1 antibody;Lef1 antibody;LEF1_HUMAN antibody;Lymphoid enhancer binding factor 1 antibody;Lymphoid enhancer-binding factor 1 antibody;T cell specific transcription factor 1 alpha antibody;T cell-specific transcription factor 1-alpha antibody;TCF 1 alpha antibody;TCF1 alpha antibody;TCF1-alpha antibody;TCF10 antibody;TCF1alpha antibody;TCF7L3 antibody;Transcription factor T cell specific 1 alpha antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.