LI Cadherin Recombinant Rabbit Monoclonal Antibody [JE60-34] (HA721895)

UNIPROT #

Q12864

PROTEIN NAME

LI Cadherin

SYNONYMS

BILL-cadherin antibody;CAD17_HUMAN antibody;Cadherin 16 antibody;Cadherin 16, formerly antibody;Cadherin 17 antibody;cadherin 17, LI cadherin (liver-intestine) antibody;cadherin, liver-intestine antibody;Cadherin-17 antibody;CDH16 antibody;CDH16, formerly antibody;Cdh17 antibody;FLJ26931 antibody;Formerly Cadherin 16 antibody;Formerly CDH16 antibody;HPT 1 antibody;HPT-1 cadherin antibody;human intestinal peptide-associated transporter HPT-1 antibody;human peptide transporter 1 antibody;Intestinal peptide-associated transporter HPT 1 antibody;Intestinal peptide-associated transporter HPT-1 antibody;LI-cadherin antibody;Liver Cadherin antibody;liver intestine cadherin antibody;Liver-intestine cadherin antibody

SUBCELLULAR LOCATION

Cell membrane

FUNCTION

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in multiple transcript variants. Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.