LNP Mouse Monoclonal Antibody [7-3] (EM1701-47)

UNIPROT #

Q9C0E8

PROTEIN NAME

LNP

SYNONYMS

lnp antibody;LNP_HUMAN antibody;Protein lunapark antibody

SEQUENCE SIMILARITIES

Belongs to the lunapark family.

TISSUE SPECIFICITY

Expressed in neural precursor cells, where it is detected at the growth-cone-like structure and branching sites of neurite-like processes.

POST-TRANSLATIONAL MODIFICATION

Myristoylated; myristoylation is necessary for the endoplasmic reticulum (ER) three-way ER tubular junction formation, but is not required neither for membrane translocation, membrane topology formation, nor for the specific localization to ER membranes.; Phosphorylated. Phosphorylation occurs at Ser-177, Ser-182, Ser-217, Ser-227, Ser-321 and Ser-384 during interphase. Phosphorylation occurs at Ser-114, Ser-153, Ser-194, Thr-211 and Ser-353 during mitosis; these phosphorylations reduce both its homodimerization and the ER three-way tubular junction formation.; Subject to proteasomal degradation following phosphorylation during mitosis.

SUBCELLULAR LOCATION

Endoplasmic reticulum.

FUNCTION

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network. May be involved in limb and central nervous system development